Is the sialic acid binding activity of the S protein involved in the enteropathogenicity of transmissible gastroenteritis virus?
Identifieur interne : 006504 ( Main/Exploration ); précédent : 006503; suivant : 006505Is the sialic acid binding activity of the S protein involved in the enteropathogenicity of transmissible gastroenteritis virus?
Auteurs : C. Krempl [Allemagne] ; H. Laude ; G. HerrlerSource :
- Advances in experimental medicine and biology [ 0065-2598 ] ; 1998.
Descripteurs français
- KwdFr :
- Acide N-acétyl-neuraminique (métabolisme), Animaux, Gastroentérite (médecine vétérinaire), Gastroentérite (virologie), Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (génétique), Glycoprotéines membranaires (métabolisme), Maladies des porcs (virologie), Protéines de l'enveloppe virale (génétique), Protéines de l'enveloppe virale (métabolisme), Suidae, Virus de la gastroentérite transmissible (métabolisme), Virus de la gastroentérite transmissible (pathogénicité).
- MESH :
- génétique : Glycoprotéines membranaires, Protéines de l'enveloppe virale.
- médecine vétérinaire : Gastroentérite.
- métabolisme : Acide N-acétyl-neuraminique, Glycoprotéines membranaires, Protéines de l'enveloppe virale, Virus de la gastroentérite transmissible.
- pathogénicité : Virus de la gastroentérite transmissible.
- virologie : Gastroentérite, Maladies des porcs.
- Animaux, Glycoprotéine de spicule des coronavirus, Suidae.
English descriptors
- KwdEn :
- Animals, Gastroenteritis (veterinary), Gastroenteritis (virology), Membrane Glycoproteins (genetics), Membrane Glycoproteins (metabolism), N-Acetylneuraminic Acid (metabolism), Spike Glycoprotein, Coronavirus, Swine, Swine Diseases (virology), Transmissible gastroenteritis virus (metabolism), Transmissible gastroenteritis virus (pathogenicity), Viral Envelope Proteins (genetics), Viral Envelope Proteins (metabolism).
- MESH :
- chemical , genetics : Membrane Glycoproteins, Viral Envelope Proteins.
- chemical , metabolism : Membrane Glycoproteins, N-Acetylneuraminic Acid, Viral Envelope Proteins.
- metabolism : Transmissible gastroenteritis virus.
- pathogenicity : Transmissible gastroenteritis virus.
- veterinary : Gastroenteritis.
- virology : Gastroenteritis, Swine Diseases.
- Animals, Spike Glycoprotein, Coronavirus, Swine.
Abstract
Transmissible gastroenteritis virus (TGEV) is able to recognize sialic acid on sialo-glycoconjugates. Analysis of mutants indicated that single point mutations in the S protein (around amino acids 145-155) of TGEV may result both in the loss of the sialic acid binding activity and in a drastic reduction of the enteropathogenicity. From this observation we conclude that the sialic acid binding activity is involved in the enteropathogenicity of TGEV. On the basis of our recent results we propose that binding of sialylated macromolecules to the virions surface may increase virus stability. This in turn would explain how TGEV as an enveloped virus can survive the gastrointestinal passage and cause intestinal infections.
DOI: 10.1007/978-1-4615-5331-1_72
PubMed: 9782329
Affiliations:
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Krempl</name><affiliation wicri:level="1"><nlm:affiliation>Institut für Virologie Philipps-Universität Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Virologie Philipps-Universität Marburg</wicri:regionArea></affiliation></author><author><name sortKey="Laude, H" sort="Laude, H" uniqKey="Laude H" first="H" last="Laude">H. Laude</name></author><author><name sortKey="Herrler, G" sort="Herrler, G" uniqKey="Herrler G" first="G" last="Herrler">G. Herrler</name></author></analytic><series><title level="j">Advances in experimental medicine and biology</title><idno type="ISSN">0065-2598</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Gastroenteritis (veterinary)</term><term>Gastroenteritis (virology)</term><term>Membrane Glycoproteins (genetics)</term><term>Membrane Glycoproteins (metabolism)</term><term>N-Acetylneuraminic Acid (metabolism)</term><term>Spike Glycoprotein, Coronavirus</term><term>Swine</term><term>Swine Diseases (virology)</term><term>Transmissible gastroenteritis virus (metabolism)</term><term>Transmissible gastroenteritis virus (pathogenicity)</term><term>Viral Envelope Proteins (genetics)</term><term>Viral Envelope Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide N-acétyl-neuraminique (métabolisme)</term><term>Animaux</term><term>Gastroentérite (médecine vétérinaire)</term><term>Gastroentérite (virologie)</term><term>Glycoprotéine de spicule des coronavirus</term><term>Glycoprotéines membranaires (génétique)</term><term>Glycoprotéines membranaires (métabolisme)</term><term>Maladies des porcs (virologie)</term><term>Protéines de l'enveloppe virale (génétique)</term><term>Protéines de l'enveloppe virale (métabolisme)</term><term>Suidae</term><term>Virus de la gastroentérite transmissible (métabolisme)</term><term>Virus de la gastroentérite transmissible (pathogénicité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Membrane Glycoproteins</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Membrane Glycoproteins</term><term>N-Acetylneuraminic Acid</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéines membranaires</term><term>Protéines de l'enveloppe virale</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Transmissible gastroenteritis virus</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Gastroentérite</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Acide N-acétyl-neuraminique</term><term>Glycoprotéines membranaires</term><term>Protéines de l'enveloppe virale</term><term>Virus de la gastroentérite transmissible</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Transmissible gastroenteritis virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus de la gastroentérite transmissible</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Gastroenteritis</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Gastroentérite</term><term>Maladies des porcs</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Gastroenteritis</term><term>Swine Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Spike Glycoprotein, Coronavirus</term><term>Swine</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Glycoprotéine de spicule des coronavirus</term><term>Suidae</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Transmissible gastroenteritis virus (TGEV) is able to recognize sialic acid on sialo-glycoconjugates. Analysis of mutants indicated that single point mutations in the S protein (around amino acids 145-155) of TGEV may result both in the loss of the sialic acid binding activity and in a drastic reduction of the enteropathogenicity. From this observation we conclude that the sialic acid binding activity is involved in the enteropathogenicity of TGEV. On the basis of our recent results we propose that binding of sialylated macromolecules to the virions surface may increase virus stability. This in turn would explain how TGEV as an enveloped virus can survive the gastrointestinal passage and cause intestinal infections.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Herrler, G" sort="Herrler, G" uniqKey="Herrler G" first="G" last="Herrler">G. Herrler</name><name sortKey="Laude, H" sort="Laude, H" uniqKey="Laude H" first="H" last="Laude">H. Laude</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Krempl, C" sort="Krempl, C" uniqKey="Krempl C" first="C" last="Krempl">C. Krempl</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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